(02-22-2021, 02:38 AM)madbluboy date Wrote:Where is the source for your Smarties data?

(02-22-2021, 02:41 AM)Mav date Wrote:Interesting article about the history of the polio vaccine(s): How a debate over two competing vaccines gripped the medical community — in 1961, Salon Click HERE.

I didn’t know there were 2 polio vaccines. I’m glad I received the flavoured Sabin sugar cube rather than the Salk jab as I hate needles and they would have needed a footy team to hold me down.

Fascinating that Sabin’s live attenuated vaccine eventually mutated to cause infections.

Just the story of the hostility between Salk & Sabin makes it worth the read. Reminds me of one of the more famous scientific fights to the death between Newton and Leibniz over who invented calculus. British mathematicians fell in behind Newton while those on the continent went the other way. Prof. Jerison from MIT argues the refusal of the British to use Leibniz’s notation set British maths back by a 100 years.

(02-22-2021, 02:41 AM)Mav link Wrote:Interesting article about the history of the polio vaccine(s): How a debate over two competing vaccines gripped the medical community — in 1961, Salon Click HERE.

I didn’t know there were 2 polio vaccines. I’m glad I received the flavoured Sabin sugar cube rather than the Salk jab as I hate needles and they would have needed a footy team to hold me down.

Fascinating that Sabin’s live attenuated vaccine eventually mutated to cause infections.
........................

Quote:Mainly because of the large-scale use of Sabin's vaccine, poliovirus has largely been eradicated from the planet. Only a few natural infections occur now, mainly in Pakistan and Afghanistan where polio is still endemic. Sabin's vaccine is a live RNA virus. While it does not thrive well in humans, it does replicate in us. Since RNA replication is error prone, the virus in the vaccine could mutate to become dangerous again. The mutated virus could spread to others and cause paralysis. Indeed, most of the cases of polio seen today outside the endemic areas are caused by such mutations of the live virus in Sabin's vaccine.

(02-22-2021, 02:52 AM)PaulP date Wrote:But a report released in July last year by the World Health Organization (WHO) may provide a poetic resolution to the debate between the two camps. The answer: a combination of both vaccines may be the most effective way to defeat the disease. After a series of trials in India in 2011 and 2012, researchers found that administering the injected vaccine alongside the live virus boosted immunity significantly. Now the WHO is recommending this approach throughout the remaining polio endemic countries.

(02-22-2021, 03:14 AM)LP link Wrote:Interestingly, there are some early rumours "cross vaccination" with different types of COVID vaccine are offering similar improved results. You can expect papers by mid-year, there is one paper out but the study is so small at less than 50 patients it's not worth referencing.

This might be the biggest issue in 3rd World locations, where an initial expensive dose to high risk populations can be followed up with a cheaper generic shot. Let's hope for good news on that front!

(02-22-2021, 02:38 AM)madbluboy link Wrote:Where is the source for your Smarties data?